Run depletes stamina, combat depletes stamina, bleeding depletes stamina, swimming depletes stamina, reduced health regeneration, increased jump/fall damage, realistic fall heights, realistic movement! And much more! ALL DYNAMIC! In a deeply way. Be strategic in your adventures, or face the consequences! Affects NPCs too.
Also for Oldrim:
https://www.nexusmods.com/skyrim/mods/109500